Journal: Medical Physics

Article Title: Exploring the potential of Raman micro‐spectroscopy of radiochromic films for experimental microdosimetry

doi: 10.1002/mp.17900

Figure Lengend Snippet: The mean ( n = 500) of the Raman spectral response of RCFs measured with a 60× WI objective over the 100 × 100 µm 2 scan area. Spectra after data preprocessing are shown for four representative doses and a control sample. WI, water immersion.

Article Snippet: It was coupled into an optical fiber with a 100 μm diameter core which delivered the signal to a Raman spectrometer (Andor Shamrock 303i) using a 100 μm slit and a 600 line/mm grating.

Techniques: Control

Journal: Medical Physics

Article Title: Exploring the potential of Raman micro‐spectroscopy of radiochromic films for experimental microdosimetry

doi: 10.1002/mp.17900

Figure Lengend Snippet: Dose response curves were generated using experimental data corresponding to the mean intensity values of the triplicate set of measurements for two different Raman peaks at (a) 1445 cm −1 and (b) 2060 cm −1 for 60× and 40× WI objectives of the custom Raman microscope. (c) Comparison of the average of three sets of data measured using the custom Raman microscope (60× WI objective) utilizing circularly polarized light versus the commercial Raman microscope (100× air objective) employing linearly polarized light. (d) Comparison of dose response curves for a representative set of doses at landscape and portrait orientations of the RCF samples using linearly polarized versus circularly polarized light. RCF, radiochromic films; WI, water immersion.

Article Snippet: It was coupled into an optical fiber with a 100 μm diameter core which delivered the signal to a Raman spectrometer (Andor Shamrock 303i) using a 100 μm slit and a 600 line/mm grating.

Techniques: Generated, Microscopy, Comparison

Journal: Medical Physics

Article Title: Exploring the potential of Raman micro‐spectroscopy of radiochromic films for experimental microdosimetry

doi: 10.1002/mp.17900

Figure Lengend Snippet: Two‐dimensional maps of the intensity of the Raman peaks at 1445 and cm −1, normalized to the monomer peak at 2260 cm −1 consisting of 10 × 10 grids over 100 × 100 µm 2 ROIs for a representative set of doses measured using a 60× WI objective on the custom microscope. ROI, region of interest; WI, water immersion.

Article Snippet: It was coupled into an optical fiber with a 100 μm diameter core which delivered the signal to a Raman spectrometer (Andor Shamrock 303i) using a 100 μm slit and a 600 line/mm grating.

Techniques: Microscopy

Journal: Medical Physics

Article Title: Exploring the potential of Raman micro‐spectroscopy of radiochromic films for experimental microdosimetry

doi: 10.1002/mp.17900

Figure Lengend Snippet: 2D Raman intensity maps measured with the 60× WI objective on the custom microscope corresponding to the response of the 1445 cm −1 peak of 20 × 20 grids of control (0 Gy) (a) and 2 Gy films (b) for a 20 × 20 µm 2 ROI. Red circles indicate areas corresponding to higher concentrations of polymer. (c) Brightfield transmission image of control film taken with the custom Raman microscope using a 40× WI objective with a representative 20 × 20 µm 2 ROI for context. ROI, region of interest; WI, water immersion.

Article Snippet: It was coupled into an optical fiber with a 100 μm diameter core which delivered the signal to a Raman spectrometer (Andor Shamrock 303i) using a 100 μm slit and a 600 line/mm grating.

Techniques: Microscopy, Control, Polymer, Transmission Assay